Receptor-ligand binding: 'Catch' bonds finally caught

被引：58

作者：

Konstantopoulos, K ^{[1
]}

Hanley, WD ^{[1
]}

Wirtz, D ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

来源：

CURRENT BIOLOGY | 2003年 / 13卷 / 15期

关键词：

D O I：

10.1016/S0960-9822(03)00529-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leukocyte recruitment to sites of inflammation is initiated by the selectin family of adhesion receptors. Recent research reveals that P-selectin binding to its ligand exhibits 'catch' to 'slip' bond transition that may help explain the shear threshold phenomenon.

引用

页码：R611 / R613

页数：3

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