The secreted integrin ligand nephronectin is necessary for forelimb formation in Xenopus tropicalis

被引：19

作者：

Abu-Daya, Anita ^{[1
]}

Nishimoto, Satoko ^{[1
]}

Fairclough, Lynn ^{[1
]}

Mohun, Timothy J. ^{[1
]}

Logan, Malcolm P. O. ^{[1
]}

Zimmerman, Lyle B. ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Dev Biol, London NW7 1AA, England

来源：

DEVELOPMENTAL BIOLOGY | 2011年 / 349卷 / 02期

基金：

英国医学研究理事会;

关键词：

Xenopus tropicalis; Genetics; Limb; Mutant; Nephronectin; Integrin; HOLT-ORAM SYNDROME; LIMB DEVELOPMENT; PROTEIN NEPHRONECTIN; KIDNEY DEVELOPMENT; MUSCLE DEVELOPMENT; MOLECULAR-BASIS; AMPHIBIAN LIMB; TBX5; INITIATION; EMBRYOS;

D O I：

10.1016/j.ydbio.2010.10.015

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

While limb regeneration has been extensively studied in amphibians, little is known about the initial events in limb formation in metamorphosing anurans. The small secreted integrin ligand nephronectin (npnt) is necessary for development of the metanephros in mouse. Although expressed in many tissues, its role in other developmental processes is not well-studied. Here we show that a transgene insertion that disrupts this gene ablates forelimb formation in Xenopus tropicalis. Our results suggest a novel role for integrin signalling in limb development, and represent the first insertional phenotype to be cloned in amphibians. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：204 / 212

页数：9

共 54 条

[1]

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo [J].

Agarwal, P ;

Wylie, JN ;

Galceran, J ;

Arkhitko, O ;

Li, CL ;

Deng, CX ;

Grosschedl, R ;

Bruneau, BG .

DEVELOPMENT, 2003, 130 (03) :623-633

[2]

T-box gene tbx5 is essential for formation of the pectoral limb bud [J].

Ahn, DG ;

Kourakis, MJ ;

Rohde, LA ;

Silver, LM ;

Ho, RK .

NATURE, 2002, 417 (6890) :754-758

[3]

Amaya E, 1999, METH MOL B, V97, P393, DOI 10.1385/1-59259-270-8:393

[4]

A large-scale insertional mutagenesis screen in zebrafish [J].

Amsterdam, A ;

Burgess, S ;

Golling, G ;

Chen, WB ;

Sun, ZX ;

Townsend, K ;

Farrington, S ;

Haldi, M ;

Hopkins, N .

GENES & DEVELOPMENT, 1999, 13 (20) :2713-2724

[5]

BALINSKY BI, 1931, ARCH ENTWMECH ORGAN, V123, P565

[6]

Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome [J].

Basson, CT ;

Bachinsky, DR ;

Lin, RC ;

Levi, T ;

Elkins, JA ;

Soults, J ;

Grayzel, D ;

Kroumpouzou, E ;

Traill, TA ;

LeblancStraceski, J ;

Renault, B ;

Kucherlapati, R ;

Seidman, JG ;

Seidman, CE .

NATURE GENETICS, 1997, 15 (01) :30-35

[7]

Beyond Early Development: Xenopus as an Emerging Model for the Study of Regenerative Mechanisms [J].

Beck, Caroline W. ;

Izpisua Belmonte, Juan Carlos ;

Christen, Bea .

DEVELOPMENTAL DYNAMICS, 2009, 238 (06) :1226-1248

[8]

Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin α8β1 in the embryonic kidney [J].

Brandenberger, R ;

Schmidt, A ;

Linton, J ;

Wang, D ;

Backus, C ;

Denda, S ;

Müller, U ;

Reichardt, LF .

JOURNAL OF CELL BIOLOGY, 2001, 154 (02) :447-458

[9]

Amphibian limb regeneration: Rebuilding a complex structure [J].

Brockes, JP .

SCIENCE, 1997, 276 (5309) :81-87

[10]

A gene trap approach in Xenopus [J].

Bronchain, OJ ;

Hartley, KO ;

Amaya, E .

CURRENT BIOLOGY, 1999, 9 (20) :1195-1198

← 1 2 3 4 5 6 →