Heparan sulphate proteoglycans:: The sweet side of development

被引：531

作者：

Häcker, U

Nybakken, K

Perrimon, N

机构：

[1] Lund Univ, Lund Ctr Stem Cell Biol & Cell Therapy, Dept Expt Med Sci, S-22184 Lund, Sweden

[2] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, Boston, MA 02175 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 07期

关键词：

D O I：

10.1038/nrm1681

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.

引用

收藏

页码：530 / 541

页数：12

相关论文

共 87 条

[31] Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc [J].

Han, C ;

Yan, D ;

Belenkaya, TY ;

Lin, XJ .

DEVELOPMENT, 2005, 132 (04) :667-679

[32] Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation [J].

Han, C ;

Belenkaya, TY ;

Khodoun, M ;

Tauchi, M ;

Lin, XD ;

Lin, XH .

DEVELOPMENT, 2004, 131 (07) :1563-1575

[33] Drosophila glypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process [J].

Han, C ;

Belenkaya, TY ;

Wang, B ;

Lin, XH .

DEVELOPMENT, 2004, 131 (03) :601-611

[34]

Herman T, 1997, COLD SPRING HARB SYM, V62, P353, DOI 10.1101/SQB.1997.062.01.042

[35] sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination [J].

Herman, T ;

Hartwieg, E ;

Horvitz, HR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (03) :968-973

[36] Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein [J].

Hu, HY .

NATURE NEUROSCIENCE, 2001, 4 (07) :695-701

[37] Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis [J].

Hwang, HY ;

Olson, SK ;

Esko, JD ;

Horvitz, HR .

NATURE, 2003, 423 (6938) :439-443

[38]

Jackson SM, 1997, DEVELOPMENT, V124, P4113

[39] Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance [J].

Johnson, KG ;

Ghose, A ;

Epstein, E ;

Lincecum, J ;

O'Connor, MB ;

Van Vactor, D .

CURRENT BIOLOGY, 2004, 14 (06) :499-504

[40] Drosophila heparan sulfate 6-O-sulfotransferase (dHS6ST) gene -: Structure, expression, and function in the formation of the tracheal system [J].

Kamimura, K ;

Fujise, M ;

Villa, F ;

Izumi, S ;

Habuchi, H ;

Kimata, K ;

Nakato, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (20) :17014-17021

← 1 2 3 4 5 6 7 8 9 →