The biological paths of IL-1 family members IL-18 and IL-33

被引：104

作者：

Smith, Dirk E. ^{[1
]}

机构：

[1] Amgen Inc, Dept Inflammat Res, Seattle, WA 98119 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2011年 / 89卷 / 03期

关键词：

cytokine; inflammation; disease; RECEPTOR ACCESSORY PROTEIN; NECROSIS-FACTOR-ALPHA; SOLUBLE ST2 PROTEIN; CD4(+) T-CELLS; CYTOKINE PRODUCTION; CUTTING EDGE; IMMUNE-RESPONSE; INTERLEUKIN-1; RECEPTOR; AIRWAY INFLAMMATION; INVARIANT NKT;

D O I：

10.1189/jlb.0810470

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cytokines are key mediators of the immune system, and few have been more thoroughly studied than those of the IL-1 family. IL-1 alpha and IL-1 beta are the founding members and now celebrate 25 years since their cloning. In that time, IL-1-directed research has illuminated many aspects of cytokine biology and innate immunity. The family is now recognized to include 11 total members, including IL-18 and IL-33, which are the topic of this review. These two inflammatory cytokines are expressed broadly, and their actions influence a variety of physiologic responses involved in inflammation and immunity. The purpose of this article is not to provide an exhaustive review of IL-18 and IL-33 but rather, to summarize what is known about their key functions and to provide perspective on their similarities and differences. J. Leukoc. Biol. 89: 383-392; 2011.

引用

页码：383 / 392

页数：10

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