AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization

被引：113

作者：

Amato, Stephen ^{[1
]}

Liu, Xiuxin ^{[2
,3
]}

Zheng, Bin ^{[4
,5
]}

Cantley, Lewis ^{[4
,5
]}

Rakic, Pasko ^{[2
,3
]}

Man, Heng-Ye ^{[1
]}

机构：

[1] Boston Univ, Dept Biol, Boston, MA 02215 USA

[2] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06510 USA

[3] Yale Univ, Sch Med, Kavli Inst Neurosci, New Haven, CT 06510 USA

[4] Beth Israel Deaconess Med Ctr, Div Signal Transduct, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

SCIENCE | 2011年 / 332卷 / 6026期

关键词：

HIPPOCAMPAL-NEURONS; BRAIN-DEVELOPMENT; AXONAL-TRANSPORT; POLARITY; TRANSLOCATION; KINESIN-1; MIGRATION; CULTURE; GROWTH; ENERGY;

D O I：

10.1126/science.1201678

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Axon-dendrite polarization is crucial for neural network wiring and information processing in the brain. Polarization begins with the transformation of a single neurite into an axon and its subsequent rapid extension, which requires coordination of cellular energy status to allow for transport of building materials to support axon growth. We found that activation of the energy-sensing adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway suppressed axon initiation and neuronal polarization. Phosphorylation of the kinesin light chain of the Kif5 motor protein by AMPK disrupted the association of the motor with phosphatidylinositol 3-kinase (PI3K), preventing PI3K targeting to the axonal tip and inhibiting polarization and axon growth.

引用

页码：247 / 251

页数：5

共 29 条

[1] Control of Cortical Axon Elongation by a GABA-Driven Ca2+/Calmodulin-Dependent Protein Kinase Cascade [J].