Defending the mucosa: adjuvant and carrier formulations for mucosal immunity

被引:103
作者
Lawson, Louise B. [1 ]
Norton, Elizabeth B. [1 ]
Clements, John D. [1 ]
机构
[1] Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA
关键词
CELL-ACTIVATING FACTOR; HEAT-LABILE TOXIN; ESCHERICHIA-COLI; DENDRITIC CELLS; CHOLERA-TOXIN; SUBLINGUAL VACCINATION; RECEPTOR EXPRESSION; PROTECTIVE IMMUNITY; INFLUENZA VACCINE; CUTTING EDGE;
D O I
10.1016/j.coi.2011.03.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A majority of infectious microorganisms either colonize or cross mucosal surfaces to enter the host. A major goal in vaccine design is to induce a protective, lasting immune response against potential pathogens at mucosal surfaces. In addition, mucosal vaccines can offer needle-free delivery, thereby improving accessibility, safety, and cost-effectiveness. Challenges to successful mucosal vaccination include poor induction of mucosal immunity, limited understanding of protective mechanisms and crosstalk between mucosal compartments, and the availability of safe, effective mucosal adjuvants and delivery systems. This review focuses on some key advances in the field of mucosal vaccinology within the past 2-3 years, including reports on promising new formulations and investigations into the mechanisms of established mucosal adjuvants and/or particulate carrier systems.
引用
收藏
页码:414 / 420
页数:7
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