Evaluation of polyethersulfone highflux hemodialysis membrane in vitro and in vivo

被引：90

作者：

Su, Bai-Hai ^{[1
,2
]}

Fu, Ping ^{[2
]}

Li, Qiu ^{[3
]}

Tao, Ye ^{[2
]}

Li, Zi ^{[2
]}

Zao, Hui-Sha ^{[2
]}

Zhao, Chang-sheng ^{[1
,4
]}

机构：

[1] Sichuan Univ, Natl Engn Res Ctr Biomat, State Key Lab Polymer Mat Engn, Chengdu 610065, Peoples R China

[2] Sichuan Univ, W China Hosp, Dept Nephrol, Chengdu 610041, Peoples R China

[3] Sichuan Univ, W China Hosp, Dept Ultrasonol, Chengdu 610041, Peoples R China

[4] Chengdu OCI Med Device Co Ltd, Chengdu 610025, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2008年 / 19卷 / 02期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1007/s10856-007-3006-9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A new hemodialysis membrane manufactured by a blend of polyethersulfone (PES) and polyvinylpyrrolidone (PVP) was evaluated in vitro and in vivo. Goat was selected as the experimental animal. The clearance and the reduction ratio after the hemodialysis of small molecules (urea, creatinine, phosphate) for the PES membrane were higher in vitro than that in vivo. The reduction ratio of beta(2)-microglobulin was about 50% after the treatment for 4 h. The biocompatibility profiles of the membranes indicated slight neutropenia and platelet adhesion at the initial stage of the hemodialysis. Electrolyte, blood gas, and blood biochemistry were also analyzed before and after the treatment. The results indicated that PES hollow fiber membrane had a potential widely use for hemodialysis.

引用

页码：745 / 751

页数：7

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