Genotypes of Pneumocystis jiroveci isolates obtained in Harare, Zimbabwe, and London, United Kingdom

被引：40

作者：

Miller, RF

Lindley, AR

Ambrose, HE

Malin, AS

Wakefield, AE

机构：

[1] UCL, Royal Free & Univ Coll Med Sch, Windeyer Inst Med Sci, Dept Sexually Transmitted Dis, London WC1E 6AU, England

[2] Univ Oxford, Weatherall Inst Mol Med, Dept Paediat, Mol Infect Dis Grp, Oxford OX3 9DU, England

[3] Univ Zimbabwe, Sch Clin, Parirenyatwa Hosp, Dept Clin Pharmacol, Harare, Zimbabwe

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 12期

关键词：

D O I：

10.1128/AAC.47.12.3979-3981.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Isolates of Pneumocystis jiroveci from sulfa-exposed and nonexposed patients from London, United Kingdom, and Harare, Zimbabwe, were genotyped. At the dihydropteroate synthase (DHPS) locus, there was evidence of selection pressure from sulfa drug exposure, and reversal of DHPS genotype ratios occurred when selection pressure was absent or was removed.

引用

页码：3979 / 3981

页数：3

共 20 条

[1]

[Anonymous], 1995, DRUG THER B, V33, P92

[2] Genetic variation in Pneumocystis carinii isolates from different geographic regions:: Implications for transmission [J].

Beard, CB ;

Carter, JL ;

Keely, SP ;

Huang, L ;

Pieniazek, NJ ;

Moura, INS ;

Roberts, JM ;

Hightower, AW ;

Bens, MS ;

Freeman, AR ;

Lee, S ;

Stringer, JR ;

Duchin, JS ;

del Rio, C ;

Rimland, D ;

Baughman, RP ;

Levy, DA ;

Dietz, VJ ;

Simon, P ;

Navin, TR .

EMERGING INFECTIOUS DISEASES, 2000, 6 (03) :265-272

[3]

Huang L, 2001, J EUKARYOT MICROBIOL, p137S

[4] Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients [J].

Kazanjian, P ;

Armstrong, W ;

Hossler, PA ;

Burman, W ;

Richardson, J ;

Lee, CH ;

Crane, L ;

Katz, J ;

Meshnick, SR .

JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (02) :551-557

[5] GENETIC-VARIATION AMONG PNEUMOCYSTIS-CARINII HOMINIS ISOLATES IN RECURRENT PNEUMOCYSTOSIS [J].

KEELY, SP ;

STRINGER, JR ;

BAUGHMAN, RP ;

LINKE, MJ ;

WALZER, PD ;

SMULIAN, AG .

JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (02) :595-598

[6] Source of Pneumocystis carinii in recurrent episodes of pneumonia in AIDS patients [J].

Keely, SP ;

Baughman, RP ;

Smulian, AG ;

Dohn, MN ;

Stringer, JR .

AIDS, 1996, 10 (08) :881-888

[7] Dihydropteroate synthase polymorphisms in Pneumocystis carinii [J].

Lane, BR ;

Ast, JC ;

Hossler, PA ;

Mindell, DP ;

Bartlett, MS ;

Smith, JW ;

Meshnick, SR .

JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (02) :482-485

[8] Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim sulfamethoxazole or dapsone use [J].

Ma, L ;

Borio, L ;

Masur, H ;

Kovacs, JA .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (06) :1969-1978

[9] PNEUMOCYSTIS-CARINII PNEUMONIA IN ZIMBABWE [J].

MALIN, AS ;

GWANZURA, LKZ ;

KLEIN, S ;

ROBERTSON, VJ ;

MUSVAIRE, P ;

MASON, PR .

LANCET, 1995, 346 (8985) :1258-1261

[10] Asymptomatic carriage of Pneumocystis jiroveci in subjects undergoing bronchoscopy:: a prospective study [J].

Maskell, NA ;

Waine, DJ ;

Lindley, A ;

Pepperell, JCT ;

Wakefield, AE ;

Miller, RF ;

Davies, RJO .

THORAX, 2003, 58 (07) :594-597

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