Status of current clinical trials in diabetic polyneuropathy

被引:11
作者
Bril, V [1 ]
机构
[1] Univ Toronto, UHN, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada
关键词
D O I
10.1017/S0317167100001335
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Peripheral polyneuropathy is the most frequent complication of diabetic mellitus. In spite of many clinical trials of different specific interventions for diabetic polyneuropathy, intensive glycemic control remains the only effective specific therapy currently available for this troublesome complication. This systematic overview reports the status of current clinical trials in diabetic polyneuropathy with an emphasis on those interventions directed towards specific pathophysiological derangements. A discussion of clinical trials of agents directed towards relieving painful symptoms of diabetic polyneuropathy concludes this overview.
引用
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页码:191 / 198
页数:8
相关论文
共 92 条
[1]  
*ADA, 2001, DIABETES CARE S1, V24, pS33
[2]   Effect of intensive diabetes treatment on nerve conduction in the diabetes control and complications trial [J].
Albers, JW ;
Kenny, DJ ;
Brown, M ;
Greene, D ;
Cleary, PA ;
Lachin, JM ;
Nathan, DM .
ANNALS OF NEUROLOGY, 1995, 38 (06) :869-880
[3]  
Apfel SC, 1999, BRAIN PATHOL, V9, P393
[4]   Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy - A randomized controled trial [J].
Apfel, SC ;
Schwartz, S ;
Adornato, BT ;
Freeman, R ;
Biton, V ;
Rendell, M ;
Vinik, A ;
Giuliani, M ;
Stevens, JC ;
Barbano, R ;
Dyck, PJ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 284 (17) :2215-2221
[5]   Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy [J].
Apfel, SC ;
Kessler, JA ;
Adornato, BT ;
Litchy, WJ ;
Sanders, C ;
Rask, CA .
NEUROLOGY, 1998, 51 (03) :695-702
[6]  
Apfel Stuart C., 1999, American Journal of Medicine, V107, p34S
[7]  
ASBURY AK, 1988, ANN NEUROL, V24, P99
[8]   Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus - A randomized controlled trial [J].
Backonja, M ;
Beydoun, A ;
Edwards, KR ;
Schwartz, SL ;
Fonseca, V ;
Hes, M ;
LaMoreaux, L ;
Garofalo, E .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (21) :1831-1836
[9]   Anticonvulsants (antineuropathics) for neuropathic pain syndromes [J].
Backonja, MM .
CLINICAL JOURNAL OF PAIN, 2000, 16 (02) :S67-S72
[10]  
Bril V, 1998, MUSCLE NERVE, V21, P1368, DOI 10.1002/(SICI)1097-4598(199811)21:11<1368::AID-MUS2>3.3.CO