Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search

被引：581

作者：

Smith, JR

Freije, D

Carpten, JD

Gronberg, H

Xu, JF

Isaacs, SD

Brownstein, MJ

Bova, GS

Guo, H

Bujnovszky, P

Nusskern, DR

Damber, JE

Bergh, A

Emanuelsson, M

Kallioniemi, OP

WalkerDaniels, J

BaileyWilson, JE

Beaty, TH

Meyers, DA

Walsh, PC

Collins, FS

Trent, JM

Isaacs, WB

机构：

[1] NIH,NATL CTR HUMAN GENOME RES,BETHESDA,MD 20892

[2] JOHNS HOPKINS UNIV,SCH MED,JAMES BUCHANAN BRADY UROL INST,BALTIMORE,MD

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,BALTIMORE,MD 21205

[4] NIMH,NIH,BETHESDA,MD 20892

[5] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,BALTIMORE,MD

[6] UNIV MICHIGAN,DEPT INTERNAL MED,ANN ARBOR,MI 48109

[7] UMEA UNIV,DEPT PATHOL,S-90187 UMEA,SWEDEN

[8] UMEA UNIV,DEPT UROL,UMEA,SWEDEN

来源：

SCIENCE | 1996年 / 274卷 / 5291期

关键词：

D O I：

10.1126/science.274.5291.1371

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.

引用

页码：1371 / 1374

页数：4

共 19 条

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