The SCID/Beige mouse as a model to investigate protection against Yersinia pestis

被引：53

作者：

Green, M ^{[1
]}

Rogers, D ^{[1
]}

Russell, P ^{[1
]}

Stagg, AJ ^{[1
]}

Bell, DL ^{[1
]}

Eley, SM ^{[1
]}

Titball, RW ^{[1
]}

Williamson, ED ^{[1
]}

机构：

[1] DERA, Chem & Biol Def Sect, Salisbury SP4 0JQ, Wilts, England

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 1999年 / 23卷 / 02期

关键词：

severe combined immunodeficient beige mouse; plague; adoptive protection; passive protection;

D O I：

10.1111/j.1574-695X.1999.tb01229.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we have shown that severe combined immunodeficient/beige mice reconstituted with hyperimmune Balb/c lymphocytes can be used as a model to demonstrate adoptive and passive protection against plague infection. Reconstitution of severe combined immunodeficient/beige mice was successful in nine out of ten mice as demonstrated by spleen colonisation and sustained circulating immunoglobulin titres. Furthermore, an increase in antibody titre was evident after a booster immunisation of reconstituted mice. Presence of circulating antibody correlated with protection against a systemic plague challenge and indicated that in reconstituted mice adoptive transfer of a functional immune system had occurred. The severe combined immunodeficient/beige mouse was also used to demonstrate passive protection against inhaled and systemic plague infection. The reconstituted severe combined immunodeficient/beige mouse model demonstrating protective immunity against plague will be further developed to identify the immune cell subsets responsible for this protection. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. Ail rights reserved.

引用

页码：107 / 113

页数：7

共 16 条

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