Transition metal abnormalities in progressive dementias

被引：64

作者：

Akatsu, Hiroyasu ^{[2
]}

Hori, Akira ^{[2
]}

Yamamoto, Takayuki ^{[2
]}

Yoshida, Mari ^{[3
]}

Mimuro, Maya ^{[3
]}

Hashizume, Yoshio ^{[2
]}

Tooyama, Ikuo ^{[4
]}

Yezdimer, Eric M. ^{[1
]}

机构：

[1] Ind Summit Technol, Parlin, NJ USA

[2] Fukushimura Hosp, Choju Med Inst, Toyohashi, Aichi, Japan

[3] Aichi Med Univ, Inst Med Sci Aging, Dept Neuropathol, Nagakute, Aichi 48011, Japan

[4] Shiga Med Univ, Res Promot Org Intractable Neurol Dis, Mol Neurosci Res Ctr, Otsu, Shiga, Japan

来源：

BIOMETALS | 2012年 / 25卷 / 02期

关键词：

Copper; Iron; Alzheimer's disease; Lewy body; Amygdala; Hippocampus; BRAIN FERRITIN IRON; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; SERUM COPPER; ZINC; HOMEOSTASIS; REDUCTION; TOXICITY; ELEMENTS; EXCESS;

D O I：

10.1007/s10534-011-9504-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Abnormal distributions of transition metals inside the brain are potential diagnostic markers for several central nervous system diseases, including Alzheimer's disease (AD), Parkinson's disease, dementia with Lewy bodies (DLB), bipolar disorders and depression. To further explore this possibility, the total concentrations of iron, zinc, copper, manganese, aluminum, chromium and cadmium were measured in post-mortem hippocampus and amygdala tissues taken from AD, DLB and Control patients. A statistically significant near fifty percent reduction in the total copper levels of AD patients was observed in both the hippocampus and amygdala. The statistical power of the hippocampus and amygdala copper analysis was found to be 86 and 74% respectively. No statistically significant deviations in the total metal concentrations were found for zinc, manganese, chromium or aluminum. Iron was found to be increased by 38% in AD amygdala tissues, but was unchanged in AD hippocampus tissues. Accounting for differences in tissue water content, as a function of both tissue type and disease state, revealed more consistencies with previous literature. To aid in the design of future experiments, the effect sizes for all tissue types and metals studied are also presented.

引用

页码：337 / 350

页数：14

共 37 条

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