In vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(L-lactic acid) fibres and porous ultra-fine poly(glycolic acid) fibres

被引：81

作者：

You, Y

Lee, SW

Youk, JH

Min, BM

Lee, SJ

Park, WH

机构：

[1] Chungnam Natl Univ, Dept Text Engn, Taejon 305764, South Korea

[2] Inha Univ, Div NanoSyst, Dept Adv Fibre Engn, Inchon 402751, South Korea

[3] Seoul Natl Univ, Coll Dent, Dept Oral Biochem, Seoul 110749, South Korea

[4] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

来源：

POLYMER DEGRADATION AND STABILITY | 2005年 / 90卷 / 03期

关键词：

poly(glycolic acid); poly(L-lactic acid); electrospinning; porous ultra-fine fibre; biodegradability;

D O I：

10.1016/j.polymdegradstab.2005.04.015

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The in vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(L-lactic acid) (PGA/PLA) fibres and porous ultra-fine PGA fibres was investigated. The non-porous ultra-fine PGA/PLA fibres were prepared by electrospinning of a PGA/PLA solution in 1, 1, 1,3,3,3-hexafluoro-2-propanol and the porous ultra-fine PGA fibres were obtained from them via selective removal of PLA with chloroform. Since PLA has a lower degradation rate than PGA, the degradation rates of the ultra-fine PGA/PLA fibres decreased with increasing content of PLA. The porous ultra-fine PGA fibres were degraded in vitro in the order of non-porous PGA > P-PGA/PLA(90/10) > P-PGA/PLA(70/30) > P-PGA/PLA(50/50) > P-PGA/PLA(30/70) due to autocatalytic hydrolysis. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：441 / 448

页数：8

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