PT-141: A melanocortin agonist for the treatment for the of sexual dysfunction

被引：78

作者：

Molinoff, PB ^{[1
]}

Shadiack, AM ^{[1
]}

Earle, D ^{[1
]}

Diamond, LE ^{[1
]}

Quon, CY ^{[1
]}

机构：

[1] Palatin Technol Inc, Cranbury, NJ 08512 USA

来源：

MELANOCORTIN SYSTEM | 2003年 / 994卷

关键词：

melanocortin receptors; melanocortin agonist; erectile dysfunction;

D O I：

10.1111/j.1749-6632.2003.tb03167.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. Administration of PT-141 to rats and nonhuman primates results in penile erections. Systemic administration of PT-141 to rats activates neurons in the hypothalamus as shown by an increase in c-Fos immunoreactivity. Neurons in the same region of the central nervous system take up pseudorabies virus injected into the corpus cavernosum of the rat penis. Administration of PT-141 to normal men and to patients with erectile dysfunction resulted in a rapid dose-dependent increase in erectile activity. The results suggest that PT-141 holds promise as a new treatment for sexual dysfunction.

引用

页码：96 / 102

页数：7

共 6 条

[1] Neuromodulation of penile erection: An overview of the role of neurotransmitters and neuropeptides [J].