Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias

被引：247

作者：

Care, RS ^{[1
]}

Valk, PJM ^{[1
]}

Goodeve, AC ^{[1
]}

Abu-Duhier, FM ^{[1
]}

Geertsma-Kleinekoort, WMC ^{[1
]}

Wilson, GA ^{[1
]}

Gari, MA ^{[1
]}

Peake, IR ^{[1
]}

Löwenberg, B ^{[1
]}

Reilly, JT ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Haematol, Rotterdam, Netherlands

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 121卷 / 05期

关键词：

c-KIT; FLT3; AML; CBF; inv(16);

D O I：

10.1046/j.1365-2141.2003.04362.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

DNA from 110 adult de novo acute myeloid leukaemia (AML) patients exhibiting either inv(16) (n = 63) or t(8;21) (n = 47) was screened for mutations in the c-KIT (exon 8 and Asp816) and FLT3 (ITD and Asp835) genes. c-KIT exon 8 mutations were found in 15/63 (23.8%) inv(16) patients and 1/47 (2.1%) t(8;21) patients. c-KIT Asp816 mutations were present in 5/63 (7.9%) inv(16) AML and 5/47 (10.6%) t(8;21) AML. FLT3 mutations were identified in five patients (7.9%) with inv(16) and three patients (5.6%) with t(8;21) AML. All mutations were mutually exclusive; 40% of inv(16) AML patients possessed either a c-KIT or FLT3 mutation. c-KIT exon 8 mutations were shown to be a significant factor adversely affecting relapse rate.

引用

页码：775 / 777

页数：3

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