DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment

被引：210

作者：

Kantarci, K

Petersen, RC

Boeve, BF

Knopman, DS

Weigand, SD

O'Brien, PC

Shiung, MM

Smith, GE

Ivnik, RJ

Tangalos, EG

Jack, CR

机构：

[1] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN 55905 USA

[5] Mayo Clin, Dept Internal Med, Rochester, MN 55905 USA

来源：

NEUROLOGY | 2005年 / 64卷 / 05期

关键词：

D O I：

10.1212/01.WNL.0000153076.46126.E9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to Alzheimer disease (AD) in amnestic mild cognitive impairment (aMCI). Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002). Magnetic resonance diffusion-weighted imaging may help identify patients with aMCI who will progress to AD as well as or better than structural MRI measures of hippocampal atrophy.

引用

页码：902 / 904

页数：3

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