Does metoprolol inhibit the cortical spreading depression?: Acute effects of systematic metropol on CSD in rats

被引：7

作者：

Alemdar, M. ^{[1
]}

Akman, Oe

Selekler, H. M.

Komsuoglu, S. S.

Ates, N.

机构：

[1] Kocaeli Univ, Fac Med, Dept Neurol, Headache Unit, Kocaeli, Turkey

[2] Kocaeli Univ, Fac Med, Dept Physiol, Kocaeli, Turkey

来源：

CEPHALALGIA | 2007年 / 27卷 / 09期

关键词：

cortical spreading depression; migraine; metoprolol;

D O I：

10.1111/j.1468-2982.2007.01390.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cortical spreading depression (CSD) is supposed to be the underlying biological basis of the migraine aura. Metoprolol was proven to be effective in migraine prophylaxis in clinical trials, but its mechanism of action has not been clarified yet. We studied direct effects of metoprolol on a continuous CSD induction model in rats. Six adult Wistar rats were anaesthetized with intraperitoneal thiopental (50 mg/kg). CSD was induced with application of 1 m KCL through a burr hole into the left frontal dura-mater, and recorded by an Ag/AgCl DC electrode on the left parietal dura-mater. After a basal recording of CSD induction during the first 40-min period, metoprolol (5 mg/kg) was infused within 4 min. Then DC recordings were maintained for a further 120 min. Any significant differences in total number and duration of CSDs before and after metoprolol administration were not detected. This study suggests that the mode of action of metoprolol in prophylaxis is not via direct CSD inhibition.

引用

页码：1010 / 1013

页数：4

共 12 条

[1]

Topiramate inhibits cortical spreading depression in rat and cat: impact in migraine aura [J].

Akerman, S ;

Goadsby, PJ .

NEUROREPORT, 2005, 16 (12) :1383-1387

[2]

PROPHYLACTIC TREATMENT OF CLASSICAL AND NON-CLASSICAL MIGRAINE WITH METOPROLOL - A COMPARISON WITH PLACEBO [J].

ANDERSSON, PG ;

DAHL, S ;

HANSEN, JH ;

HANSEN, PE ;

HEDMAN, C ;

KRISTENSEN, TN ;

OLIVARIUS, BD .

CEPHALALGIA, 1983, 3 (04) :207-212

[3]

Suppression of cortical spreading depression in migraine prophylaxis [J].

Ayata, C ;

Jin, HW ;

Kudo, C ;

Dalkara, T ;

Moskowitz, MA .

ANNALS OF NEUROLOGY, 2006, 59 (04) :652-661

[4]

Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model [J].

Bolay, H ;

Reuter, U ;

Dunn, AK ;

Huang, ZH ;

Boas, DA ;

Moskowitz, MA .

NATURE MEDICINE, 2002, 8 (02) :136-142

[5]

From spreading depression to the trigeminovascular system [J].

Dalkara, T. ;

Zervas, N. T. ;

Moskowitz, M. A. .

NEUROLOGICAL SCIENCES, 2006, 27 (Suppl 2) :S86-S90

[6]

Stimulation of β-adrenoceptors activates astrocytes and provides neuroprotection [J].

Junker, V ;

Becker, A ;

Hühne, R ;

Zembatov, M ;

Ravati, A ;

Culmsee, C ;

Krieglstein, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 446 (1-3) :25-36

[7]

METOPROLOL AND PROPRANOLOL IN THE PROPHYLACTIC TREATMENT OF CLASSICAL AND COMMON MIGRAINE - A DOUBLE-BLIND-STUDY [J].

KANGASNIEMI, P ;

HEDMAN, C .

CEPHALALGIA, 1984, 4 (02) :91-96

[8]

ANTIMIGRAINE COMPOUNDS FAIL TO MODULATE THE PROPAGATION OF CORTICAL SPREADING DEPRESSION IN THE CAT [J].

KAUBE, H ;

GOADSBY, PJ .

EUROPEAN NEUROLOGY, 1994, 34 (01) :30-35

[9]

BRAIN AND CEREBROSPINAL-FLUID DISTRIBUTIONS OF METOPROLOL IN RATS [J].

NAKAZONO, T ;

MURAKAMI, T ;

SAKAI, S ;

HIGASHI, Y ;

YATA, N .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1992, 15 (06) :295-302

[10]

Selective β1-blockade improves cardiac bioenergetics and function and decreases neuroendocrine activation in rats during early postinfarct remodeling [J].

Omerovic, E ;

Bollano, E ;

Mobini, R ;

Madhu, B ;

Kujacic, V ;

Soussi, B ;

Hjalmarson, Å ;

Waagstein, F .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 281 (02) :491-498

← 1 2 →