Nerve growth factor inhibits sympathetic neurons' response to an injury cytokine

被引:35
作者
Shadiack, AM [1 ]
Vaccariello, SA [1 ]
Sun, Y [1 ]
Zigmond, RE [1 ]
机构
[1] Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA
关键词
D O I
10.1073/pnas.95.13.7727
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Axonal damage to adult peripheral neurons causes changes in neuronal gene expression. For example, axotomized sympathetic, sensory, and motor neurons begin to express galanin mRNA and protein, and recent evidence suggests that galanin plays a role in peripheral nerve regeneration. Previous studies in sympathetic and sensory neurons have established that galanin expression is triggered by two consequences of nerve transection: the induction of leukemia inhibitory factor (LIF) and the reduction in the availability of the target-derived factor, nerve growth factor. It is shown in the present study that no stimulation of galanin expression occurs following direct application of LIF to intact neurons in the superior cervical sympathetic ganglion. Injection of animals with an antiserum to nerve growth factor concomitant with the application of LIF, on the other hand, does stimulate galanin expression. The data suggest that the response of neurons to an injury factor, LIF, is affected by whether the neurons still receive trophic signals from their targets.
引用
收藏
页码:7727 / 7730
页数:4
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