Protein adsorption on topographically nanostructured titanium

被引：51

作者：

Galli, C ^{[1
]}

Coen, MC

Hauert, R

Katanaev, VL

Wymann, MP

Gröning, P

Schlapbach, L

机构：

[1] Univ Fribourg, Dept Solid State Phys, CH-1700 Fribourg, Switzerland

[2] Univ Fribourg, Inst Biochem, CH-1700 Fribourg, Switzerland

[3] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

[4] Swiss Fed Labs Mat Testing & Res, EMPA, CH-8600 Dubendorf, Switzerland

来源：

SURFACE SCIENCE | 2001年 / 474卷 / 1-3期

关键词：

atomic force microscopy; surface structure; morphology; roughness; and topography; chemisorption; titanium oxide; biological molecules - proteins;

D O I：

10.1016/S0039-6028(00)01054-2

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We study the protein adsorption on surfaces in order to investigate their predominant role in biocompatibility. Nanostructures are created by local anodic oxidation on titanium using the atomic force microscope. A remarkable specificity of the actin filament adsorption on the nanostructure height is noticed. F-actin is observed to have a low adsorption on nanostructures of a height of 4 nm and the adsorbed proteins appear to be randomly oriented. In contrast high protein adsorption is observed for structure height between 1 and 2 nm, moreover the filaments adsorb preferentially parallel to the nanostructured pattern. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：L180 / L184

页数：5

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