Postinfluenza Bacterial Pneumonia: Host Defenses Gone Awry

被引：73

作者：

Ballinger, Megan N. ^{[1
]}

Standiford, Theodore J. ^{[1
]}

机构：

[1] Univ Michigan, Div Pulm & Crit Care Med, Dept Med, Med Ctr, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2010年 / 30卷 / 09期

关键词：

INFLUENZA-VIRUS INFECTION; STREPTOCOCCUS-PNEUMONIAE; INCREASED SUSCEPTIBILITY; A VIRUS; NEUTROPHIL RECRUITMENT; DENDRITIC CELLS; H1N1; INFLUENZA; MOUSE MODEL; T-CELLS; IRAK-M;

D O I：

10.1089/jir.2010.0049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Influenza is a common respiratory pathogen causing both seasonal and pandemic disease. Influenza infection predisposes the host to secondary bacterial infection of the respiratory tract, which is a major cause of both morbidity and mortality in flu-related disease. In this review, we will discuss innate and adaptive antiviral responses during influenza infection, and review how these responses modulate protective immunity against secondary bacterial pathogens of the lung. Specific emphasis will be placed on implications of bacterial superinfection and mechanisms involved.

引用

页码：643 / 652

页数：10

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