Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering

被引：61

作者：

Choi, Colin K. ^{[1
]}

Breckenridge, Mark T. ^{[1
]}

Chen, Christopher S. ^{[1
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

TRENDS IN CELL BIOLOGY | 2010年 / 20卷 / 12期

基金：

美国国家卫生研究院;

关键词：

TRACTION FORCE MICROSCOPY; ACTIN STRESS FIBERS; EXTRACELLULAR-MATRIX; FOCAL ADHESIONS; REGULATES GROWTH; CONJUGATED VEGF; 3D ENVIRONMENTS; MIGRATION; INTEGRINS; SHAPE;

D O I：

10.1016/j.tcb.2010.09.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Cells constantly probe and respond to a myriad of cues that are present in their local surroundings The effects of soluble cues are relatively straightforward to manipulate, yet teasing apart how cells transduce signals from the extracellular matrix and neighboring cells has proven to be challenging due to the spatially and mechanically complex adhesive interactions Over the years advances in the engineering of biocompatible materials have enabled innovative ways to study adhesion-mediated cell functions, and numerous insights have elucidated the significance of the cellular microenvironment Here, we highlight some of the major approaches and discuss the potential for future advancement

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收藏

页码：705 / 714

页数：10

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