Defects of lipoprotein metabolism in familial combined hyperlipidaemia

被引:59
作者
de Graaf, J [1 ]
Stalenhoef, AFH [1 ]
机构
[1] Univ Nijmegen Hosp, Dept Med, Div Gen Internal Med, NL-6500 HB Nijmegen, Netherlands
关键词
D O I
10.1097/00041433-199806000-00002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Familial combined hyperlipidaemia is the most common inherited hyperlipidaemia and is found in up to 10% of patients with premature myocardial infarction, The genetic and metabolic bases of the disorder have not yet been defined. This review discusses the important advances in the past year in our understanding of the different metabolic pathways contributing to the pathogenesis of familial combined hyperlipidaemia, Curr Opin Lipidol 9;189-196. (C) 1998 Lippincott Raven Publishers.
引用
收藏
页码:189 / 196
页数:8
相关论文
共 80 条
[1]   A familial combined hyperlipidemic kindred with impaired apolipoprotein B catabolism - Kinetics of apolipoprotein B during placebo and pravastatin therapy [J].
AguilarSalinas, CA ;
Barrett, PHR ;
Pulai, J ;
Zhu, XL ;
Schonfeld, G .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (01) :72-82
[2]  
AGUILARSALINAS CA, 1995, J LIPID RES, V36, P188
[3]   Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia [J].
Aitman, TJ ;
Godsland, IF ;
Farren, B ;
Crook, D ;
Wong, HJ ;
Scott, J .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (04) :748-754
[4]  
ARAD Y, 1990, J LIPID RES, V31, P567
[5]   Is familial combined hyperlipidaemia a genetic disorder of adipose tissue? [J].
Arner, P .
CURRENT OPINION IN LIPIDOLOGY, 1997, 8 (02) :89-94
[6]   Influence of obesity on plasma lipoproteins, glycaemia and insulinaemia in patients with familial combined hyperlipidaemia [J].
Ascaso, JF ;
Sales, J ;
Merchante, A ;
Real, J ;
Lorente, R ;
MartinezValls, J ;
Carmena, R .
INTERNATIONAL JOURNAL OF OBESITY, 1997, 21 (05) :360-366
[7]   INHERITANCE OF LOW-DENSITY-LIPOPROTEIN SUBCLASS PATTERNS IN FAMILIAL COMBINED HYPERLIPIDEMIA [J].
AUSTIN, MA ;
BRUNZELL, JD ;
FITCH, WL ;
KRAUSS, RM .
ARTERIOSCLEROSIS, 1990, 10 (04) :520-530
[8]  
AUSTIN MA, 1988, JAMA-J AM MED ASSOC, V260, P1917
[9]   ATHEROGENIC LIPOPROTEIN PHENOTYPE - A PROPOSED GENETIC-MARKER FOR CORONARY HEART-DISEASE RISK [J].
AUSTIN, MA ;
KING, MC ;
VRANIZAN, KM ;
KRAUSS, RM .
CIRCULATION, 1990, 82 (02) :495-506
[10]   LACK OF EVIDENCE FOR LINKAGE BETWEEN LOW-DENSITY-LIPOPROTEIN SUBCLASS PHENOTYPES AND THE APOLIPOPROTEIN-B LOCUS IN FAMILIAL COMBINED HYPERLIPIDEMIA [J].
AUSTIN, MA ;
WIJSMAN, E ;
GUO, SW ;
KRAUSS, RM ;
BRUNZELL, JD ;
DEEB, S .
GENETIC EPIDEMIOLOGY, 1991, 8 (05) :287-297