Expression of thyroid hormone receptors is disturbed in human renal clear cell carcinoma

被引：60

作者：

Puzianowska-Kuznicka, M

Nauman, A

Madej, A

Tanski, Z

Cheng, SY

Nauman, J ^{[1
]}

机构：

[1] Polish Acad Sci, Med Res Ctr, Dept Endocrinol, Warsaw, Poland

[2] Med Ctr Postgrad Educ, Dept Biochem, Warsaw, Poland

[3] Univ Med Sch, Dept Med & Endocrinol, PL-02097 Warsaw, Poland

[4] Reg Hosp, Dept Urol, Ostroleka, Poland

[5] NCI, Gene Regulat Sect, Mol Biol Lab, Bethesda, MD 20892 USA

来源：

CANCER LETTERS | 2000年 / 155卷 / 02期

关键词：

human renal clear cell carcinoma; thyroid hormone receptor; gene expression; protein expression; tumorigenesis;

D O I：

10.1016/S0304-3835(00)00416-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human renal clear cell carcinoma (RCCC) accounts for up to 2% of human cancers. To find out if thyroid hormone (T3) and its receptors (TRs) play a role in tumorigenesis of RCCC, the expression of TRs was evaluated on mRNA and protein level. It was found that TR alpha (both alpha1 and alpha2) mRNA amount was significantly decreased in tumors while compared with healthy kidney tissue, and this decrease was deepest in G1 (well differentiated) RCCCs. In contrast, TR alpha1 protein was 1.6 x overexpressed in tumors. TR beta1 mRNA amount was overexpressed in 30% and significantly decreased in 70% of examined tumors. On the protein level, TR beta1 amount was 1.7 x lower in tumors than in healthy controls. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：145 / 152

页数：8

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