Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene, aph(3')-IIb, in Pseudomonas aeruginosa

被引：53

作者：

Hachler, H

Santanam, P

Kayser, FH

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 05期

关键词：

D O I：

10.1128/AAC.40.5.1254

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A novel, probably chromosomally encoded, aminoglycoside phosphotransferase gene was cloned on a 2,996-bp PstI fragment from Pseudomonas aeruginosa and designated aph(3')-IIb. It coded for a protein of 268 amino acids that showed 51.7% amino acid identity with APH(3')-II [APH(3') is aminoglycoside-3'-phosphotransferase] from Tn5. Two other open reading frames on the cloned fragment showed homology to a signal-transducing system in P. aeruginosa.

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页码：1254 / 1256

页数：3

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