Blocking interleukin-1β in acute and chronic autoinflammatory diseases

被引：119

作者：

Dinarello, C. A. ^{[1
]}

机构：

[1] Univ Colorado, Dept Med, Aurora, CO USA

来源：

JOURNAL OF INTERNAL MEDICINE | 2011年 / 269卷 / 01期

关键词：

cytokines; diabetes; heart failure; inflammation; TUMOR-NECROSIS-FACTOR; IL-L-BETA; FACTOR-ALPHA; IN-VIVO; RHEUMATOID-ARTHRITIS; RECEPTOR ANTAGONIST; MONONUCLEAR-CELLS; INSULIN SENSITIVITY; MULTIPLE-MYELOMA; DROSOPHILA TOLL;

D O I：

10.1111/j.1365-2796.2010.02313.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dinarello CA (Department of Medicine, University of Colorado, Aurora, CO, USA). Blocking interleukin-1 beta in acute and chronic autoinflammatory diseases. (Key Symposium) J Intern Med 2011; 269: 16-28. An expanding spectrum of acute and chronic inflammatory diseases is considered 'autoinflammatory' diseases. This review considers autoinflammatory diseases as being distinct from 'autoimmune' diseases. Autoimmune diseases are associated with dysfunctional T cells and treated with 'biologicals', including antitumour necrosis factor alpha, CTLA-Ig, anti-IL-12/23, anti-CD20, anti-IL-17 and anti-IL-6 receptor. In contrast, autoinflammatory diseases are uniquely attributed to a dysfunctional monocyte caspase 1 activity and secretion of IL-1 beta; indeed, blocking IL-1 beta results in a rapid and sustained reduction in the severity of most autoinflammatory diseases. Flares of gout, type 2 diabetes, heart failure and smouldering multiple myeloma are examples of seemingly unrelated diseases, which are uniquely responsive to IL 1 beta neutralization.

引用

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页码：16 / 28

页数：13

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