Blocking interleukin-1β in acute and chronic autoinflammatory diseases

被引:119
作者
Dinarello, C. A. [1 ]
机构
[1] Univ Colorado, Dept Med, Aurora, CO USA
关键词
cytokines; diabetes; heart failure; inflammation; TUMOR-NECROSIS-FACTOR; IL-L-BETA; FACTOR-ALPHA; IN-VIVO; RHEUMATOID-ARTHRITIS; RECEPTOR ANTAGONIST; MONONUCLEAR-CELLS; INSULIN SENSITIVITY; MULTIPLE-MYELOMA; DROSOPHILA TOLL;
D O I
10.1111/j.1365-2796.2010.02313.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Dinarello CA (Department of Medicine, University of Colorado, Aurora, CO, USA). Blocking interleukin-1 beta in acute and chronic autoinflammatory diseases. (Key Symposium) J Intern Med 2011; 269: 16-28. An expanding spectrum of acute and chronic inflammatory diseases is considered 'autoinflammatory' diseases. This review considers autoinflammatory diseases as being distinct from 'autoimmune' diseases. Autoimmune diseases are associated with dysfunctional T cells and treated with 'biologicals', including antitumour necrosis factor alpha, CTLA-Ig, anti-IL-12/23, anti-CD20, anti-IL-17 and anti-IL-6 receptor. In contrast, autoinflammatory diseases are uniquely attributed to a dysfunctional monocyte caspase 1 activity and secretion of IL-1 beta; indeed, blocking IL-1 beta results in a rapid and sustained reduction in the severity of most autoinflammatory diseases. Flares of gout, type 2 diabetes, heart failure and smouldering multiple myeloma are examples of seemingly unrelated diseases, which are uniquely responsive to IL 1 beta neutralization.
引用
收藏
页码:16 / 28
页数:13
相关论文
共 96 条
[1]   Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction [J].
Abbate, Antonio ;
Salloum, Fadi N. ;
Vecile, Elena ;
Das, Anindita ;
Hoke, Nicholas N. ;
Straino, Stefania ;
Biondi-Zoccai, Giuseppe G. L. ;
Houser, Jon-Erik ;
Qureshi, Ian Z. ;
Ownby, Evan D. ;
Gustini, Edoardo ;
Biasucci, Luigi M. ;
Severino, Anna ;
Capogrossi, Maurizio C. ;
Vetrovec, George W. ;
Crea, Filippo ;
Baldi, Alfonso ;
Kukreja, Rakesh C. ;
Dobrina, Aldo .
CIRCULATION, 2008, 117 (20) :2670-2683
[2]   Interleukin-1β modulation using a genetically engineered antibody prevents adverse cardiac remodelling following acute myocardial infarction in the mouse [J].
Abbate, Antonio ;
Van Tassell, Benjamin W. ;
Seropian, Ignacio M. ;
Toldo, Stefano ;
Robati, Roshanak ;
Varma, Amit ;
Salloum, Fadi N. ;
Smithson, Lisa ;
Dinarello, Charles A. .
EUROPEAN JOURNAL OF HEART FAILURE, 2010, 12 (04) :319-322
[3]   Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study) [J].
Abbate, Antonio ;
Kontos, Michael C. ;
Grizzard, John D. ;
Biondi-Zoccai, Giuseppe G. L. ;
Van Tassell, Benjamin W. ;
Robati, Roshanak ;
Roach, Lenore M. ;
Arena, Ross A. ;
Roberts, Charlotte S. ;
Varma, Amit ;
Gelwix, Christopher C. ;
Salloum, Fadi N. ;
Hastillo, Andrea ;
Dinarello, Charles A. ;
Vetrovec, George W. .
AMERICAN JOURNAL OF CARDIOLOGY, 2010, 105 (10) :1371-1377
[4]   Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage [J].
Abramson, SB ;
Amin, A .
RHEUMATOLOGY, 2002, 41 (09) :972-980
[5]   NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].
Agostini, L ;
Martinon, F ;
Burns, K ;
McDermott, MF ;
Hawkins, PN ;
Tschopp, J .
IMMUNITY, 2004, 20 (03) :319-325
[6]   Phospholipases C and A2 control lysosome-mediated IL-1β secretion:: Implications for inflammatory processes [J].
Andrei, C ;
Margiocco, P ;
Poggi, A ;
Lotti, LV ;
Torrisi, MR ;
Rubartelli, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9745-9750
[7]   The secretory route of the leaderless protein interleukin 1β involves exocytosis of endolysosome-related vesicles [J].
Andrei, C ;
Dazzi, C ;
Lotti, L ;
Torrisi, MR ;
Chimini, G ;
Rubartelli, A .
MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (05) :1463-1475
[8]   NUCLEOTIDE-SEQUENCE OF HUMAN MONOCYTE INTERLEUKIN-1 PRECURSOR CDNA [J].
AURON, PE ;
WEBB, AC ;
ROSENWASSER, LJ ;
MUCCI, SF ;
RICH, A ;
WOLFF, SM ;
DINARELLO, CA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (24) :7907-7911
[9]   CYTOTOXICITY OF HUMAN PI-7 INTERLEUKIN-1 FOR PANCREATIC-ISLETS OF LANGERHANS [J].
BENDTZEN, K ;
MANDRUPPOULSEN, T ;
NERUP, J ;
NIELSEN, JH ;
DINARELLO, CA ;
SVENSON, M .
SCIENCE, 1986, 232 (4757) :1545-1547
[10]   Effects of etanercept in patients with the metabolic syndrome [J].
Bernstein, LE ;
Berry, J ;
Kim, S ;
Canavan, B ;
Grinspoon, SK .
ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (08) :902-908