c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

被引：147

作者：

Kanazawa, S

Soucek, L

Evan, G

Okamoto, T

Peterlin, BM

机构：

[1] Univ Calif San Francisco, Rosalind Russell Med Res Ctr, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Rosalind Russell Med Res Ctr, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[4] Nagoya City Univ, Sch Med, Dept Mol Genet, Nagoya, Aichi 467, Japan

来源：

ONCOGENE | 2003年 / 22卷 / 36期

基金：

美国国家卫生研究院;

关键词：

c-Myc; P-TEFb; CycT1; apoptosis; proliferation; transcription;

D O I：

10.1038/sj.onc.1206800

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc.

引用

页码：5707 / 5711

页数：5

共 26 条

[1] THE C-MYC PROTEIN INDUCES CELL-CYCLE PROGRESSION AND APOPTOSIS THROUGH DIMERIZATION WITH MAX
AMATI, B
LITTLEWOOD, TD
EVAN, GI
LAND, H
[J]. EMBO JOURNAL, 1993, 12 (13) : 5083 - 5087
[2] NF-κB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II
Barboric, M
Nissen, RM
Kanazawa, S
Jabrane-Ferrat, N
Peterlin, BM
[J]. MOLECULAR CELL, 2001, 8 (02) : 327 - 337
[3] c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
Baudino, TA
McKay, C
Pendeville-Samain, H
Nilsson, JA
Maclean, KH
White, EL
Davis, AC
Ihle, JN
Cleveland, JL
[J]. GENES & DEVELOPMENT, 2002, 16 (19) : 2530 - 2543
[4] POINT MUTATIONS IN THE C-MYC TRANSACTIVATION DOMAIN ARE COMMON IN BURKITTS-LYMPHOMA AND MOUSE PLASMACYTOMAS
BHATIA, K
HUPPI, K
SPANGLER, G
SIWARSKI, D
IYER, R
MAGRATH, I
[J]. NATURE GENETICS, 1993, 5 (01) : 56 - 61
[5] Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo
Chao, SH
Price, DH
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (34) : 31793 - 31799
[6] Myc-mediated transformation: the repression connection
Claassen, GF
Hann, SR
[J]. ONCOGENE, 1999, 18 (19) : 2925 - 2933
[7] CLARK HM, 1994, CANCER RES, V54, P3383
[8] c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism
Eberhardy, SR
Farnham, PJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) : 48562 - 48571
[9] EBERHARDY SR, 2002, J BIOL CHEM
[10] INDUCTION OF APOPTOSIS IN FIBROBLASTS BY C-MYC PROTEIN
EVAN, GI
WYLLIE, AH
GILBERT, CS
LITTLEWOOD, TD
LAND, H
BROOKS, M
WATERS, CM
PENN, LZ
HANCOCK, DC
[J]. CELL, 1992, 69 (01) : 119 - 128

← 1 2 3 →