Unravelling small world networks

被引:24
作者
Higham, DJ [1 ]
机构
[1] Univ Strathclyde, Dept Math, Glasgow G1 1XH, Lanark, Scotland
[2] Fields Inst Res Math Sci, Toronto, ON, Canada
关键词
adjacency matrix; bandwidth; bioinformatics; Cuthill-McKee; envelope; genome datasets; laplacian; maximum likelihood; minimum degree; proteome networks; random graph; reordering; small world phenomenon; sparse matrix; two-sum;
D O I
10.1016/S0377-0427(03)00471-0
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
New classes of random graphs have recently been shown to exhibit the small world phenomenon-they are clustered like regular lattices and yet have small average pathlengths like traditional random graphs. Small world behaviour has been observed in a number of real life networks, and hence these random graphs represent a useful modelling tool. In particular, Grindrod [Phys. Rev. E 66 (2002) 066702-1] has proposed a class of range dependent random graphs for modelling proteome networks in bioinformatics. A property of these graphs is that, when suitably ordered, most edges in the graph are short-range, in the sense that they connect near-neighbours, and relatively few are long-range. Grindrod also looked at an inverse problem-given a graph that is known to be an instance of a range dependent random graph, but with vertices in arbitrary order, can we reorder the vertices so that the short-range/long-range connectivity structure is apparent? When the graph is viewed in terms of its adjacency matrix, this becomes a problem in sparse matrix theory: find a symmetric row/column reordering that places most nonzeros close to the diagonal. Algorithms of this general nature have been proposed for other purposes, most notably for reordering to reduce fill-in and for clustering large data sets. Here, we investigate their use in the small world reordering problem. Our numerical results suggest that a spectral reordering algorithm is extremely promising, and we give some theoretical justification for this observation via the maximum likelihood principle. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:61 / 74
页数:14
相关论文
共 28 条
[1]   Whole-genome expression analysis: challenges beyond clustering [J].
Altman, RB ;
Raychaudhuri, S .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2001, 11 (03) :340-347
[2]  
[Anonymous], P 3 EUR C ECDL 99
[3]   Small worlds [J].
Barbour, AD ;
Reinert, G .
RANDOM STRUCTURES & ALGORITHMS, 2001, 19 (01) :54-74
[4]   A SPECTRAL ALGORITHM FOR ENVELOPE REDUCTION OF SPARSE MATRICES [J].
BARNARD, ST ;
POTHEN, A ;
SIMON, H .
NUMERICAL LINEAR ALGEBRA WITH APPLICATIONS, 1995, 2 (04) :317-334
[5]   Cluster analysis and display of genome-wide expression patterns [J].
Eisen, MB ;
Spellman, PT ;
Brown, PO ;
Botstein, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14863-14868
[6]   Performance of data networks with random links [J].
Fuks, H ;
Lawniczak, AT .
MATHEMATICS AND COMPUTERS IN SIMULATION, 1999, 51 (1-2) :101-117
[7]   An analysis of spectral envelope reduction via quadratic assignment problems [J].
George, A ;
Pothen, A .
SIAM JOURNAL ON MATRIX ANALYSIS AND APPLICATIONS, 1997, 18 (03) :706-732
[8]  
Gleiss P. M., 2001, J. Adv. ComplexSyst, V04, P207, DOI [10.1142/s0219525901000140, DOI 10.1142/S0219525901000140]
[9]   Range-dependent random graphs and their application to modeling large small-world Proteome datasets [J].
Grindrod, P .
PHYSICAL REVIEW E, 2002, 66 (06) :7
[10]  
Grindrod Peter, 2003, Am J Pharmacogenomics, V3, P1, DOI 10.2165/00129785-200303010-00001