Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia

被引：38

作者：

Ernst, Thomas ^{[1
,2
]}

Score, Joannah ^{[1
,2
]}

Deininger, Michael ^{[3
]}

Hidalgo-Curtis, Claire ^{[1
,2
]}

Lackie, Peter ^{[4
]}

Ershler, William B. ^{[5
]}

Goldman, John M. ^{[6
]}

Cross, Nicholas C. P. ^{[1
,2
]}

Grand, Francis H. ^{[1
,2
]}

机构：

[1] Univ Southampton, Wessex Reg Genet Lab, Salisbury SP2 8BJ, Wilts, England

[2] Univ Southampton, Sch Med, Div Human Genet, Southampton, Hants, England

[3] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[4] Univ Southampton, Sch Med, Div Infect Inflammat & Immun, Southampton, Hants, England

[5] Harbor Hosp, Hematol Immunol Unit, Baltimore, MD USA

[6] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Dept Haematol, London, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2011年 / 153卷 / 01期

关键词：

ABL1; FOXP1; SNX2; ALL; acute lymphoblastic leukaemia; TRANSCRIPT;

D O I：

10.1111/j.1365-2141.2010.08457.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>We have identified two novel ABL1 fusion genes in two patients with B-cell acute lymphoblastic leukaemia (ALL) associated with a t(3;9)(p12;q34) and a t(5;9)(q23;q34), respectively. Molecular analysis revealed a FOXP1-ABL1 fusion for the t(3;9) and a SNX2-ABL1 fusion for the t(5;9). The fusions were confirmed by specific amplification of the genomic breakpoints using reverse transcription polymerase chain reaction. The identification of ALL with rare ABL1 fusion partners is important because the leukaemia may respond to tyrosine kinase inhibitors in the same way as ALL patients with a classical BCR-ABL1 fusion gene.

引用

页码：43 / 46

页数：4

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