New phthalimide derivatives with potent analgesic activity: II

被引：69

作者：

Antunes, R

Batista, H

Srivastava, RM ^{[1
]}

Thomas, G

Araujo, CC

机构：

[1] Univ Fed Pernambuco, Dept Quim Fundamental, Recife, PE, Brazil

[2] Univ Fed Paraiba, LTF, Lab Tecnol Farmaceut, BR-58059900 Joao Pessoa, Paraiba, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(98)00558-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven new phthalimide derivatives (9a similar to g) with 1,2,4-oxadiazol-5-yl methyl group attached to nitrogen have been synthesized from N-phthaloylglycine 6 and arylamidoximes 7a similar to g. All of these showed potent analgesic effect with acetic acid induced "writhing" test in mice. One of the better compounds (ID50 = 2.2 mg/Kg ip) has been found to be 9a which also demonstrates analgesic activity against inflammatory pain. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3071 / 3076

页数：6

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