Cyclin-dependent kinase 5 in amyotrophic lateral sclerosis

被引：54

作者：

Nguyen, MD

Julien, JP

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[2] Univ Laval, CHU Laval, Res Ctr, St Foy, PQ G1V 4G2, Canada

来源：

NEUROSIGNALS | 2003年 / 12卷 / 4-5期

关键词：

cyclin-dependent kinase 5; neurodegeneration; amyotrophic lateral sclerosis; cell cycle; cytoskeleton; Alzheimer's disease;

D O I：

10.1159/000074623

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyotrophic lateral sclerosis is a neurological disorder that selectively affects motor neurons of brain and spinal cord. Emerging evidence indicates an involvement of the serine/threonine-cyclin-dependent kinase 5 (Cdk5) in the pathogenesis. Deregulation of Cdk5 by its truncated co-activators, p25 and p29, contributes to neurodegeneration by altering the phosphorylation state of cytosolic and cytoskeletal proteins and, possibly, through the induction of cell cycle regulators. The present paper reviews these findings and proposes new perspectives to decipher the mechanisms of neurodegeneration in amyotrophic lateral sclerosis induced by Cdk5. Copyright (C) 2003 S. Karger AG, Basel.

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页码：215 / 220

页数：6

相关论文

共 48 条

[1] Hyperphosphorylated tan and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5 [J].

Ahlijanian, MK ;

Barrezueta, NX ;

Williams, RD ;

Jakowski, A ;

Kowsz, KP ;

McCarthy, S ;

Coskran, T ;

Carlo, A ;

Seymour, PA ;

Burkhardt, JE ;

Nelson, RB ;

McNeish, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) :2910-2915

[2] Cyclin-dependent kinase-5 is associated with lipofuscin in motor neurones in amyotrophic lateral sclerosis [J].

Bajaj, NPS ;

Al-Sarraj, ST ;

Anderson, V ;

Kibble, M ;

Leigh, N ;

Miller, CCJ .

NEUROSCIENCE LETTERS, 1998, 245 (01) :45-48

[3]

BATES S, 1994, ONCOGENE, V9, P71

[4] Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice [J].

Bian, F ;

Nath, R ;

Sobocinski, G ;

Booher, RN ;

Lipinski, WJ ;

Callahan, MJ ;

Pack, A ;

Wang, KKW ;

Walker, LC .

JOURNAL OF COMPARATIVE NEUROLOGY, 2002, 446 (03) :257-266

[5] Changes in the expression of novel Cdk5 activator messenger RNA (p39(nck5ai) mRNA) during rat brain development [J].

Cai, XH ;

Tomizawa, K ;

Tang, DM ;

Lu, YF ;

Moriwaki, A ;

Tokuda, M ;

Nagahata, S ;

Hatase, O ;

Matsui, H .

NEUROSCIENCE RESEARCH, 1997, 28 (04) :355-360

[6] Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity [J].

Carey, RG ;

Li, BG ;

DiCicco-Bloom, E .

JOURNAL OF NEUROSCIENCE, 2002, 22 (05) :1583-1591

[7] From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS [J].

Cleveland, DW ;

Rothstein, JD .

NATURE REVIEWS NEUROSCIENCE, 2001, 2 (11) :806-819

[8] A decade of CDK5 [J].

Dhavan, R ;

Tsai, LH .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (10) :749-759

[9] E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3 [J].

Giovanni, A ;

Keramaris, E ;

Morris, EJ ;

Hou, ST ;

O'Hare, M ;

Dyson, N ;

Robertson, GS ;

Slack, RS ;

Park, DS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (16) :11553-11560

[10] Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis [J].

Gong, XM ;

Tang, XL ;

Wiedmann, M ;

Wang, XM ;

Peng, JM ;

Zheng, D ;

Blair, LAC ;

Marshall, J ;

Mao, ZX .

NEURON, 2003, 38 (01) :33-46

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