Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity

被引:35
作者
Nam, NH
You, YJ
Kim, Y
Hong, DH
Kim, HM
Ahn, BZ [1 ]
机构
[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea
[2] Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea
关键词
D O I
10.1016/S0960-894X(01)00165-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of 3-aryl-7-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1, 1-dimethoxy-5,8-dione)naphthalenyl]-2- propenoates (8ba, 8bb) and (E3)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa, 9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the or ortho- or para-dihydroxy functionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1173 / 1176
页数:4
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