Muscle fiber and satellite cell apoptosis in the aging human thyroarytenoid muscle: A stereological study with confocal laser scanning microscopy

被引：31

作者：

Malmgren, LT ^{[1
]}

Jones, CE ^{[1
]}

Bookman, LM ^{[1
]}

机构：

[1] SUNY Upstate Med Univ, Dept Otolaryngol & Commun Sci, Syracuse, NY 13210 USA

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2001年 / 125卷 / 01期

关键词：

D O I：

10.1067/mhn.2001.116449

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

OBJECTIVE: This study determines the role of changes in numerical densities of apoptotic myonuclei and satellite cells in age-related remodeling of the thyroarytenoid muscle CTA). DESIGN: Changes in numerical densities of apoptotic myonuclei and satellite cells were estimated for the entire TA by using stereological techniques. RESULTS: There was an increase in N-v (apoptotic myonucreus,) (fiber type) (P < 0.05) and in the percentage of apoptotic myonuclei (P < 0.05) in type 1 but not in type 2 muscle fibers. There was also an increase in N-v apoptotic satellite cell,N- fiber type (P < 0.05) and in the percentage of apoptotic satellite cells (P < 0.05) in type 1 fibers but not in type 2 fibers. CONCLUSION Apoptosis may contribute to age-related fiber loss and atrophy in the TA. SIGNIFICANCE: Therapeutic techniques based on decreasing the frequency of apoptosis may block age-related fiber loss and atrophy in the TA.

引用

页码：34 / 39

页数：6

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