PAF-mediated pulmonary edema:: a new role for acid sphingomyelinase and ceramide

被引：244

作者：

Göggel, R

Winoto-Morbach, S

Vielhaber, G

Imai, Y

Lindner, K

Brade, L

Brade, H

Ehlers, S

Slutsky, AS

Schütze, S

Gulbins, E

Uhlig, S ^{[1
]}

机构：

[1] Leibniz Ctr Med & Biosci, Res Ctr Borstel, D-23845 Borstel, Germany

[2] Univ Kiel, Inst Immunol, D-24105 Kiel, Germany

[3] St Michaels Hosp, Toronto, ON M5B 1W8, Canada

[4] Univ Essen Gesamthsch, D-45122 Essen, Germany

来源：

NATURE MEDICINE | 2004年 / 10卷 / 02期

关键词：

D O I：

10.1038/nm977

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by PAF, endotoxin or acid instillation. Our results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury.

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页码：155 / 160

页数：6

相关论文

共 45 条

[1] MODIFICATIONS OF SPHINGOMYELIN AND PHOSPHATIDYLCHOLINE METABOLISM BY TRICYCLIC ANTIDEPRESSANTS AND PHENOTHIAZINES [J].

ALBOUZ, S ;

LESAUX, F ;

WENGER, D ;

HAUW, JJ ;

BAUMANN, N .

LIFE SCIENCES, 1986, 38 (04) :357-363

[2] Inflammatory activation of arachidonic acid signaling in murine P388D(1) macrophages via sphingomyelin synthesis [J].

Balsinde, J ;

Balboa, MA ;

Dennis, EA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (33) :20373-20377

[3] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[4] ACUTE CIRCULATORY COLLAPSE CAUSED BY PLATELET-ACTIVATING FACTOR (PAF-ACETHER) IN DOGS [J].

BESSIN, P ;

BONNET, J ;

APFFEL, D ;

SOULARD, C ;

DESGROUX, L ;

PELAS, I ;

BENVENISTE, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 86 (3-4) :403-413

[5]

BLIGH EG, 1959, CAN J BIOCHEM PHYSIO, V37, P912

[6] CORTICOSTEROID INHIBITION OF AIRWAY MICROVASCULAR LEAKAGE [J].

BOSCHETTO, P ;

ROGERS, DF ;

FABBRI, LM ;

BARNES, PJ .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 143 (03) :605-609

[7] AN ARTIFICIAL GLYCOCONJUGATE CONTAINING THE BISPHOSPHORYLATED GLUCOSAMINE DISACCHARIDE BACKBONE OF LIPID-A BINDS LIPID-A MONOCLONAL-ANTIBODIES [J].

BRADE, L ;

HOLST, O ;

BRADE, H .

INFECTION AND IMMUNITY, 1993, 61 (10) :4514-4517

[8] Platelet-activating factor mediates pulmonary macromolecular leak following intestinal ischemia-reperfusion [J].

Carter, MB ;

Wilson, MA ;

Wead, WB ;

Garrison, RN .

JOURNAL OF SURGICAL RESEARCH, 1996, 60 (02) :403-408

[9] Dexamethasone suppresses tumor necrosis factor-α-induced apoptosis in osteoblasts:: Possible role for ceramide [J].

Chae, HJ ;

Chae, SW ;

Kang, JS ;

Bang, BG ;

Cho, SB ;

Park, RK ;

So, HS ;

Kim, YK ;

Kim, HM ;

Kim, HR .

ENDOCRINOLOGY, 2000, 141 (08) :2904-2913

[10] PLATELET-ACTIVATING-FACTOR MEDIATES HEMODYNAMIC-CHANGES AND LUNG INJURY IN ENDOTOXIN-TREATED RATS [J].

CHANG, SW ;

FEDDERSEN, CO ;

HENSON, PM ;

VOELKEL, NF .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (05) :1498-1509

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