Semaphorins command cells to move

被引：403

作者：

Kruger, RR

Aurandt, J

Guan, KL

机构：

[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Inst Life Sci, Inst Gerontol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Inst Life Sci, Neurosci Program, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Inst Life Sci, Dept Biol Chem, Ann Arbor, MI 48109 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 10期

关键词：

D O I：

10.1038/nrm1740

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Semaphorins are secreted or transmembrane proteins that regulate cell motility and attachment in axon guidance, vascular growth, immune cell regulation and tumour progression. The main receptors for semaphorins are plexins, which have established roles in regulating Rho-family GTPases. Recent work shows that plexins can also influence R-Ras, which, in turn, can regulate integrins. Such regulation is probably a common feature of semaphorin signalling and contributes substantially to our understanding of semaphorin biology.

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页码：789 / 800

页数：12

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