Extramedullary disease in acute promyelocytic leukemia

被引：51

作者：

Evans, GD ^{[1
]}

Grimwade, DJ ^{[1
]}

机构：

[1] Addenbrookes Hosp, Dept Haematol, Cambridge CB2 2QQ, England

来源：

LEUKEMIA & LYMPHOMA | 1999年 / 33卷 / 3-4期

关键词：

APL; ATRA; extramedullary leukemia; CNS leukemia; adhesion molecules;

D O I：

10.3109/10428199909058422

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

All-transretinoic acid (ATRA) is currently recommended as standard treatment for acute promyelocytic leukemia (APL). However there has been increasing concern that ATRA is associated with unusual sites of relapse. Although there is insufficient evidence so far to substantiate this, we review the potential mechanisms by which ATRA may increase the incidence of extramedullary and, in particular, central nervous system (CNS) relapse.

引用

页码：219 / 229

页数：11

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