Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus

被引：76

作者：

Cheng, SJ

Nguyen, MH

Zhang, ZD

Jia, HY

Handfield, M

Clancy, CJ

机构：

[1] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA

[2] Univ Florida, Coll Med, Dept Med, Gainesville, FL USA

[3] Univ Florida, Coll Dent, Dept Oral Biol, Gainesville, FL 32610 USA

[4] Univ Florida, Coll Dent, Ctr Mol Microbiol, Gainesville, FL 32610 USA

[5] N Florida S Georgia VA Med Ctr, Gainesville, FL 32608 USA

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 10期

关键词：

D O I：

10.1128/IAI.71.10.6101-6103.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Reintroducing URA3 to its native locus in Candida albicans not5, not3, bur2, and kell disruption mutants enabled us to directly compare strains with control strain CAI-12. We showed that URA3 position affected orotidine 5'-monophosphate decarboxylase activity, hyphal morphogenesis, adherence, and mortality in murine disseminated candidiasis. After URA3 was reintroduced to its native locus, only NOT5 could be conclusively ascribed a role in virulence.

引用

页码：6101 / 6103

页数：3

共 12 条

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