Connecting Fanconi anemia to BRCA1

被引：12

作者：

Joenje, H ^{[1
]}

Arwert, F ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet & Human Genet, Amsterdam, Netherlands

来源：

NATURE MEDICINE | 2001年 / 7卷 / 04期

关键词：

D O I：

10.1038/86458

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The genetic basis of Fanconi anemia (FA) is mysterious and complex, as none of the five genes previously associated with the disorder have homology to genes encoding proteins of known function. The product of a sixth, newly-cloned FA-associated gene has been linked to BRCA1, and may finally offer some insight into the mechanism by which FA increases cancer susceptibility.

引用

页码：406 / 407

页数：2

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