Local and systemic immune responses to rectal administration of recombinant cholera toxin B subunit in humans

被引：49

作者：

Jertborn, M

Nordström, I

Kilander, A

Czerkinsky, C

Holmgren, J

机构：

[1] Univ Gothenburg, Sahlgrenska Hosp, Dept Med Microbiol & Immunol, Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrenska Hosp, Dept Infect Dis, Gothenburg, Sweden

[3] Univ Gothenburg, Sahlgrenska Hosp, Inst Internal Med, Dept Gastroenterol, Gothenburg, Sweden

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 06期

关键词：

D O I：

10.1128/IAI.69.6.4125-4128.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The induction of immune responses to rectally administered recombinant cholera toxin B subunit (CTB) in humans was studied. Three immunizations induced high levels of CTB-specific antibody-secreting cells, particular of the immunoglobulin A isotype, in both rectum and peripheral blood. Antitoxin antibody responses in rectal secretions and serum were also found.

引用

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页码：4125 / 4128

页数：4

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