Cortex controls multisensory depression in superior colliculus

被引:55
作者
Jiang, W [1 ]
Stein, BE [1 ]
机构
[1] Wake Forest Univ, Bowman Gray Sch Med, Dept Neurobiol & Anat, Winston Salem, NC 27157 USA
关键词
D O I
10.1152/jn.00369.2003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Multisensory depression is a fundamental index of multisensory integration in superior colliculus (SC) neurons. It is initiated when one sensory stimulus ( auditory) located outside its modality-specific receptive field degrades or eliminates the neuron's responses to another sensory stimulus ( visual) presented within its modality-specific receptive field. The present experiments demonstrate that the capacity of SC neurons to engage in multisensory depression is strongly dependent on influences from two cortical areas ( the anterior ectosylvian and rostral lateral suprasylvian sulci). When these cortices are deactivated, the ability of SC neurons to synthesize visual-auditory inputs in this way is compromised; multisensory responses are disinhibited, becoming more vigorous and in some cases indistinguishable from responses to the visual stimulus alone. Although obtaining a more robust multisensory SC response when cortex is nonfunctional than when it is functional may seem paradoxical, these data may help explain previous observations that the loss of these cortical influences permits visual orientation behavior in the presence of a normally disruptive auditory stimulus.
引用
收藏
页码:2123 / 2135
页数:13
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