Treatable traits: toward precision medicine of chronic airway diseases

被引：734

作者：

Agusti, Alvar ^{[1
,2
]}

Bel, Elisabeth ^{[3
]}

Thomas, Mike ^{[4
]}

Vogelmeier, Claus ^{[5
,6
]}

Brusselle, Guy ^{[7
,8
]}

Holgate, Stephen ^{[9
]}

Humbert, Marc ^{[10
]}

Jones, Paul ^{[11
]}

Gibson, Peter G. ^{[12
,13
]}

Vestbo, Jorgen ^{[14
]}

Beasley, Richard ^{[15
]}

Pavord, Ian D. ^{[16
]}

机构：

[1] Univ Barcelona, Resp Inst, Hosp Clin, IDIBAPS, Barcelona, Spain

[2] CIBER Enfermedades Resp CIBERES, Madrid, Spain

[3] Univ Amsterdam, Dept Resp Med, Acad Med Ctr, Amsterdam, Netherlands

[4] Univ Southampton, Primary Care & Populat Sci, Southampton, Hants, England

[5] Univ Marburg, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, D-35032 Marburg, Germany

[6] German Ctr Lung Res DZL, Hannover, Germany

[7] Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium

[8] Erasmus MC, Dept Epidemiol & Resp Med, Rotterdam, Netherlands

[9] Univ Southampton, Dept Clin & Expt Sci, Fac Med, Southampton Gen Hosp, Southampton, Hants, England

[10] Univ Paris 11, Serv Pneumol, Hop Bicetre, AP HP,INSERM,UMR S 999, Le Kremlin Bicetre, France

[11] St Georges Univ London, London, England

[12] Univ Newcastle, Hunter Med Res Inst, John Hunter Hosp, Dept Resp & Sleep Med, Callaghan, NSW 2308, Australia

[13] Univ Newcastle, Prior Res Ctr Asthma & Resp Dis, Callaghan, NSW 2308, Australia

[14] Univ Hosp South Manchester NHS Fdn Trust, Ctr Resp Med & Allergy, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[15] Med Res Inst New Zealand, Wellington, New Zealand

[16] Univ Oxford, Resp Med Unit, Nuffield Dept Med, NDM Res Bldg, Oxford, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2016年 / 47卷 / 02期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; EXHALED NITRIC-OXIDE; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; BLOOD EOSINOPHIL COUNTS; PERSONALIZED MEDICINE; SPUTUM EOSINOPHILIA; ASTHMA CONTROL; DOUBLE-BLIND; MULTIDIMENSIONAL ASSESSMENT;

D O I：

10.1183/13993003.01359-2015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as "treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations". In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.

引用

页码：410 / 419

页数：10

共 76 条

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