RNA localisation in the nervous system

被引：39

作者：

Dahm, Ralf ^{[1
]}

Kiebler, Michael ^{[1
]}

Macchi, Paolo ^{[1
]}

机构：

[1] Univ Vienna, Ctr Brain Res, Div Neuronal Cell Biol, A-1090 Vienna, Austria

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 02期

关键词：

RNA localisation; local translation; neurons; nervous system; synaptic plasticity;

D O I：

10.1016/j.semcdb.2007.01.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The localisation of specific RNAs is a widely employed mechanism to generate asymmetry in various biological systems, e.g. during embryonic development and cellular differentiation. Here, we highlight the importance of RNA localisation in mature neurons. Specific examples of mRNAs localised in neurons are those encoding Arc, beta-actin, CaMKII alpha and MAP2. Moreover, non-coding RNAs, such as BC1/BC200 and microRNAs (miRNAs), which play important roles in the translational regulation of localised mRNAs, receive increasing attention. The process of RNA localisation, including RNP biogenesis, transport, anchoring and translational control, and the importance of RNA localisation for the function of the nervous system are discussed. (C) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：216 / 223

页数：8

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