Protein-PCNA interactions: a DNA-scanning mechanism?

被引:132
作者
Kelman, Z [1 ]
Hurwitz, J [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Biol Mol, New York, NY 10021 USA
关键词
D O I
10.1016/S0968-0004(98)01223-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Proliferating-cell nuclear antigen (PCNA) plays an essential role in nucleic-acid metabolism in all eukaryotes. The PCNA protein interacts with a large number of proteins. These proteins can be divided into two groups: the first contains proteins that have a known enzymatic activity; the second contains regulatory proteins that are involved in cell-cycle progression, checkpoint control and cellular differentiation. Interestingly, all of the enzymes known to interact with PCNA either recognize specific structures on DNA or have limited DNA-sequence specificity. Proteins that have low sequence specificities could utilize PCNA as an adapter in order to interact with their DNA substrates.
引用
收藏
页码:236 / 238
页数:3
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