A new convenient synthesis of 1-(3-hydroxy-4-methoxyphenyl)ethane-1,2-diol (iso-MHPG) and its enantiomers.

被引：10

作者：

Fisher, AJ ^{[1
]}

Kerrigan, F ^{[1
]}

机构：

[1] Knoll Pharmaceut, Dept Res & Dev, Nottingham NG1 1GF, England

来源：

SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 16期

关键词：

D O I：

10.1080/00397919808004875

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A safe and efficient process has been developed for the multigram synthesis of 1-(3-hydroxy-4-methoxyphenyl)ethane- l,2-diol (iso-MHPG) 2, via osmium-catalysed dihydroxylation of 3-benzyloxy-4-methoxystyrene 5, and subsequent debenzylation. The methodology has been extended to an asymmetric synthesis of both enantiomers.

引用

页码：2959 / 2968

页数：10

共 11 条

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