Gold catalysis:: Proof of arene oxides as intermediates in the phenol synthesis

被引：171

作者：

Hashmi, ASK

Rudolph, M

Weyrauch, JP

Wöelfle, M

Frey, W

Bats, JW

机构：

[1] Univ Stuttgart, Inst Organ Chem, D-70569 Stuttgart, Germany

[2] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60439 Frankfurt, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 18期

关键词：

arene oxides; density functional calculations; gold; homogeneous catalysis; N ligands;

D O I：

10.1002/anie.200462672

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) An elusive intermediate in the gold-catalyzed phenol synthesis was elucidated by modifying the energy profile of this process. Thus, the use of a ligand based on 2-hydroxymethylpyridine enabled the first observation of the intermediate arene oxide, which can be enriched to account for up to 80% of the material in the reaction mixture at room temperature (see scheme). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2798 / 2801

页数：4

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