The dual effects of interleukin-18 in tumor progression

被引：44

作者：

Park, Sunyoung ^{[1
]}

Cheon, Soyoung ^{[1
]}

Cho, Daeho ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Dept Life Sci, Yonsan Ku, Seoul 140742, South Korea

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2007年 / 4卷 / 05期

关键词：

IL-18; Th1 immune response; NK cytotoxicity; tumor progression; immune escape;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Interleukin-18 (IL-18) was discovered as an interferon-gamma-inducing factor and had a critical role in inflammatory and immune response. It stimulates natural killer (NK) and T cells and enhances Th1 immune response. These activated immune cells eliminate cancer cells and virus-infected cells effectively. However, IL-18 has also been found to promote tumor progression. Higher expression or secretion level of IL-18 is detected in various cancer cells in comparison with normal control, and IL-18 is able to induce angiogenesis, migration/metastasis, proliferation and immune escape. These dual effects and the mechanism of IL-18 need to be investigated further as it relates to cancer.

引用

页码：329 / 335

页数：7

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