Diversity and complexity of ceramide signalling in apoptosis

被引：100

作者：

Okazaki, T ^{[1
]}

Kondo, T ^{[1
]}

Kitano, T ^{[1
]}

Tashima, M ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Hematol Oncol, Sakyo Ku, Kyoto 6068507, Japan

来源：

CELLULAR SIGNALLING | 1998年 / 10卷 / 10期

关键词：

ceramide; sphingolipid; stress; apoptosis; signalling; drug resistance;

D O I：

10.1016/S0898-6568(98)00035-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sphingolipid ceramide has emerged as a lipid messenger of cell functions including differentiation and apoptosis. Diverse kinds of stresses (ultraviolet, irradiation, heat shock and hypoxia) and biological factors (TNF-alpha, IFN-gamma and Fas antibody) require ceramide generation to execute apoptosis. The review summarises the diversity and complexity of up- and downstream of ceramide signalling in apoptosis and clinical implications of ceramide induced apoptosis. CELL SIGNAL 10;10:685-692, 1998. (C) 1998 Elsevier Science Inc.

引用

页码：685 / 692

页数：8

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