An explicit spatial model of yeast microcolony growth

被引：19

作者：

Jönsson, H

Levchenko, A

机构：

[1] Lund Univ, Dept Theoret Phys, Complex Syst Div, S-22362 Lund, Sweden

[2] Johns Hopkins Univ, Whitehead Inst Biomed Engn, Dept Biomed Engn, Baltimore, MD 21218 USA

来源：

MULTISCALE MODELING & SIMULATION | 2005年 / 3卷 / 02期

关键词：

yeast colony; cell adhesion; cell division; deterministic modeling;

D O I：

10.1137/040603255

中图分类号：

O1 [数学];

学科分类号：

0701 ; 070101 ;

摘要：

Here we present a single-cell-based model of cell-cell interactions in a growing yeast colony. We examine the influence of multiple factors on the colony morphology and switch to a foraging growth behavior. We find that the cell-growth inhibition by neighboring cells along with polar division growth patterns are the most significant factors driving the exploratory behavior of a colony.

引用

页码：346 / 361

页数：16

共 22 条

[1]

Braus GH, 2003, MOL BIOL CELL, V14, P4272, DOI 10.1091/mbc.E03-01-0042

[2] Cell polarity in yeast [J].