Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

被引：192

作者：

Chen, Cen ^{[1
,2
]}

Bai, Xue ^{[1
]}

Ding, Yahui ^{[3
,4
]}

Lee, In-Seop ^{[5
]}

机构：

[1] Zhejiang Sci Tech Univ, Coll Life Sci & Med, Hangzhou 310018, Peoples R China

[2] Zhejiang Prov Key Lab Silkworm Bioreactor & Biome, Hangzhou 310018, Peoples R China

[3] Zhejiang Prov Peoples Hosp, Dept Cardiol, Hangzhou 310014, Peoples R China

[4] Hangzhou Med Coll, Peoples Hosp, Hangzhou 310014, Peoples R China

[5] Yonsei Univ, Inst Nat Sci, 134 Shinchon Dong, Seoul 03722, South Korea

来源：

BIOMATERIALS RESEARCH | 2019年 / 23卷 / 01期

基金：

新加坡国家研究基金会; 中国国家自然科学基金;

关键词：

Electrical stimulation; Tissue engineered materials; Regenerative medicine;

D O I：

10.1186/s40824-019-0176-8

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence intracellular microenvironment, as a result, affect cell migration, cell proliferation, and cell differentiation. Electrical stimulation is using in tissue engineering as a novel type of tool in regeneration medicine. Besides, with the advantages of biocompatible conductive materials coming into view, the combination of electrical stimulation with suitable tissue engineered scaffolds can well combine the benefits of both and is ideal for the field of regenerative medicine. In this review, we summarize the various materials and latest technologies to deliver electrical stimulation. The influences of electrical stimulation on cell alignment, migration and its underlying mechanisms are discussed. Then the effect of electrical stimulation on cell proliferation and differentiation are also discussed.

引用

页数：12

共 135 条

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