Of mice and rats: Key species variations in the sexual differentiation of brain and behavior

被引：78

作者：

Bonthuis, P. J. ^{[2
]}

Cox, K. H. ^{[2
]}

Searcy, B. T. ^{[3
]}

Kumar, P. ^{[3
]}

Tobet, S. ^{[3
]}

Rissman, E. F. ^{[1
,2
]}

机构：

[1] Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

[2] Univ Virginia, Grad Program Neurosci, Charlottesville, VA USA

[3] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2010年 / 31卷 / 03期

关键词：

Hypothalamus; Calbindin D28k; Progestin receptor; Estrogen receptor; Nitric oxide; Sexual dimorphism; ESTROGEN-RECEPTOR-ALPHA; ADULT PARTNER PREFERENCE; NITRIC-OXIDE SYNTHASE; ANTEROVENTRAL PERIVENTRICULAR NUCLEUS; EXOGENOUS NEONATAL ANDROGEN; MAIN OLFACTORY EPITHELIUM; CALCIUM-BINDING PROTEINS; INTACT MALE RATS; PREOPTIC AREA; LORDOSIS BEHAVIOR;

D O I：

10.1016/j.yfrne.2010.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mice and rats are important mammalian models in biomedical research. In contrast to other biomedical fields, work on sexual differentiation of brain and behavior has traditionally utilized comparative animal models. As mice are gaining in popularity, it is essential to acknowledge the differences between these two rodents. Here we review neural and behavioral sexual dimorphisms in rats and mice, which highlight species differences and experimental gaps in the literature, that are needed for direct species comparisons. Moving forward, investigators must answer fundamental questions about their chosen organism, and attend to both species and strain differences as they select the optimal animal models for their research questions. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：341 / 358

页数：18

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