Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

被引：35

作者：

Shimakoshi, H ^{[1
]}

Kaieda, T ^{[1
]}

Matsuo, T ^{[1
]}

Sato, H ^{[1
]}

Hisaeda, Y ^{[1
]}

机构：

[1] Kyushu Univ, Dept Chem & Biochem, Grad Sch Engn, Fukuoka 8128581, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 28期

关键词：

dicobalt complex; cobalt-carbon bond; water-soluble; DNA cleavage;

D O I：

10.1016/S0040-4039(03)01252-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by H-1 NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：5197 / 5199

页数：3

共 12 条

[1]

[Anonymous], PROGR INORG CHEM

[2] SYNTHESIS AND PROPERTIES OF POLYIMIDAZOPYRROLONES [J].